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Why do constitutional isomers crystallize so differently?

Graduate student Noalle Fellah and Alex Shtukenberg, joined by undergraduates Carolyn Zhang and Catherine Chen, Tony Hu and Bart Kahr reported the puzzling crystallization behaviors of nicotinamide and isonicotinamide, each forming eight polymorphs but differing in the number of polymorphs from solution or melt crystallization. Read the article here.